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David Williams

Academic Wage Appt - Salaried
david.williams [at] oregonstate.edu

Office: 541-737-3277

Linus Pauling Science Center

Linus Pauling Science Center 473

2900 Southwest Campus Way

2900 Southwest Campus Way
Corvallis, OR 97331

My research interests focus on environmental carcinogens with an emphasis on polycyclic aromatic hydrocarbons (PAHs), formed from the incomplete combustion of carbon materials (coal, wood, petroleum, etc.).  We seek to determine not only how these chemicals cause cancer but also approaches for prevention and intervention, primarily by diet.  Past studies have employed trout, zebrafish and mice.  Currently, we are utilizing accelerator mass spectrometry, capable of detection at attomole (10-18) to zeptomole (10-21) levels allowing us to safely (FDA-IND) dose humans with carcinogens at levels at or below average daily exposures.  This allows, for the first time, to study the absorption, metabolism and excretion of these chemicals in humans which will benefit regulatory agencies such as the EPA that are required to set safe limit of exposure but currently have to rely on animal data employing typically a million-times the average exposure.  I am an Investigator in The Linus Pauling Institute and in this study we are examining how phytochemicals found in cruciferous vegetables can protect humans from these chemical carcinogens by reducing their absorption or enhancing the rate of detoxication and excretion.

GRANT SUPPORT (as PI or project leader)

Past Support:

NIH‑R23 HL35473, "A Novel FAD‑Containing Monooxygenase in Lung", $152,950 (total), 8/1/86‑7/31/89 (this New Investigator Research Award was converted to a FIRST Award on 4/1/87).

OSU Marine/Freshwater Biomedical Sciences Center, "Peroxidative Pathways of Carcinogenesis in Trout", $14,992, 2/1/88-1/31/89.

  1. Lung Association of Oregon, "Metabolism of Xenobiotics by Lung Flavin‑Containing Monooxygenase", $14,130, 6/1/88‑5/31/89.

NIH‑R29 HL38650, "Novel FAD‑Containing Monooxygenase in Lung", $507,450 (total), 4/1/87‑3/31/92.

NIH-P01 ES04766, "Rainbow Trout: A Model for Environmental Carcinogenesis", Dr. Williams, PI on Project 6, "Peroxidative Pathways of Carcinogenesis in Trout", $549,120 (total for project 6), 9/1/88-4/30/94.

NIH-R01 HL38650, "Flavin-Containing Monooxygenase in Lung", $524,163 (total), 4/1/92-6/30/97.

OSU Environmental Health Sciences Center, "Xenobiotic Metabolism by Nasal Monooxygenases", $13,490,

7/1/92-6/30/93.

OSU Marine/Freshwater Biomedical Sciences Center, "Carcinogenicity of Fumonisin B1 in Trout", $15,000, 7/1/96-6/30/97.

OSU Environmental Health Sciences Center, "Dietary Ginseng as a Modulator of Carcinogenesis", $24,993, 7/1/96-6/30/97.

NIH-R01 HL38650, "Flavin-Containing Monooxygenase in Lung", $1,600,790 (total), 7/1/97-6/30/05.

NIH-T35 ES007316, “Short-Term Research Training for Minority Students”, $81,000 (total), 04/01/98-3/31/03

NIH‑P01 ES04766, "Rainbow Trout: A Model for Environmental Carcinogenesis", Dr. Williams PI on Project 3, "Promotion by Indole-3-Carbinol and Ah Receptor Agonists", $809,300 (total for Project 3), 5/1/94‑4/30/00.

Oregon State University, Building Use Credits, “Building Tank Aeration System for the Food Toxicology and Nutrition Laboratory”, $31,376 (FY 2001-2002).

Oregon State University, Building Use Credits, “Renovation of Weniger 427 for a Fish Culture Lab”, $13,318, (FY 2002-2003).

NIH-T32 ES07060-26, "Mode of Action of Environmental Toxicants", $2,603,200 (total), 7/1/04-6/30/09 (PI until 6/30/06). Note- This training grant was voluntarily transferred to another PI.

NIH-P30 ES03850-19, “Marine and Freshwater Biomedical Sciences Center”, $2,175,000 (total), 4/1/04-3/31/09. Note: The NIEHS combined the two Centers at Oregon State University; as part of that agreement, Dr. Williams (PI) gave up this P30 two years early.

NIH-P01 CA90890-06, “Comparative Mechanisms of Cancer Chemoprevention”, Dr. Williams PI on Project 2, “Transplacental Chemoprotection and GI Bioavailability”, $1,448,560 (total), 3/1/03-2/29/08.

NIH- R01 ES013534, “Ultra-Low Dose Carcinogen Testing with the Trout Model”, $1,988,400 (total), 7/1/05-9/30/09.

NIH- P42 ES016465-05S1, K.C. Donnelly Supplement to SRP, $10,800 (total) 04/01/13-03/31/14.

NIH- P42 ES016465-05S2, K.C. Donnelly Supplement to SRP, $10,800 (total) 04/01/13-03/31/14.

Allergan- ATX ALGN 1205 Williams Drugs Development, “ALGN Activity of Monooxygenases”, $44,706 (total), 4/1/2005-12/31/2005.

NIH-R01 HL38650-24, “Flavin-Containing Monooxygenase in Lung”, $1,460,000 (total), 3/1/10-2/28/14

NIH- P01 CA90890-11 Rod Dashwood (PI) NIH/NCI- “Comparative Mechanisms of Cancer Chemoprevention (competing renewal)”, Dr. Williams, Director of Project 2- “Epigenetic Mechanisms of Transplacental Cancer Chemoprevention:”, $1,752,000 (total) for project 2, 4/1/10-3/31/16.

OHSU/OSU Cancer Prevention and Control Initiative Pilot Projects- “Zebrafish as a Model for Chemoprevention of T-Cell Lymphoblastic Leukemia (T-ALL)”, $50,00, 1/1/16-12/31/16.

Role (PI)

OSU Agriculture Research Foundation (ARF), “Phytochemical Supplement From Cruciferous Vegetables and Protection of the Fetus from Exposure to Carcinogens: Role of Long Non-Coding RNAs”, $12,500, 02/1/16-1/31/18.

Role (PI)

 

Current Support:

NIH- P42 ES016465-07, “PAHs: New Technologies and Emerging Health Risks”, $3.1 million (annual total), 4/1/09-3/31/19.

NIH- T32ES007060-37, “Integrated Regional Training Program in Environmental Health Sciences”, This training grant provides funding for 5 predoctoral and 3 postdoctoral trainees.

Role (Co-I)

NIH- NIEHS, “Benzo[a]pyrene Micro-dosing of Humans: A New Tool for Exposure, Risk Assessment and Prevention”, R01 ES028600-01A1, 01-01-2018-11/30/2022, $2.51 million (total), Williams, PI, Smith and Tilton, co-Is.

At OSU

Affiliated with: 
Enviro / Molecular Toxic
Headquarters: 
OSU Main Campus
I accept graduate students for the Environmental and Molecular Toxicology Department
Courses Taught: 

TOX 411/511- Fundamentals in Toxicology

Beyond OSU

Personal Interests: 

Rainy days, long walks on the beach, working for world peace

Biography

EDUCATION

 

Reed College: B.A. in Biology, 1975

Thesis: "Effect of Chronic Low Level Exposure to 4,4'‑Dichlorobiphenyl on the Liver Microsomal Metabolism of Steroids in Rana pipens"

Oregon State University: M.S. in Biochemistry, 1981

Thesis: “Analysis of Cytochrome P‑450 Isozymes from Rat Liver and Studies on the Mechanism of Induction"

Oregon State University: Ph.D. in Biochemistry, 1982

Thesis: "Purification, Characterization and Comparative Properties of Hepatic Mixed‑Function Oxidase

Enzymes from Rat and Rainbow Trout"

 

EXPERIENCE

06/16-present Affiliate Member, OHSU Knight Cancer Institute Program Leaders Group, Cancer Prevention and Control Research Program

04/09-12/14 Director, Superfund Research Center, Oregon State University

01/02-03/09 Director, Marine/Freshwater Biomedical Sciences Center, Oregon State University.

07/98-06/01 Chief, Cancer Chemoprevention Program, Linus Pauling Institute, Oregon State University.

07/97-present Professor, Dept. Environmental and Molecular Toxicology, Oregon State University.

03/07-09/07 Interim Dept. Head, Environmental and Molecular Toxicology, Oregon State University

07/95-06/97 Professor, Dept. Food Sci. & Tech. and Toxicology Prog., Oregon State University.

07/94-06/06 Director, NIEHS Toxicology Training Grant, Oregon State University.

07/91-12/01 Deputy Director, Marine/Freshwater Biomedical Sciences Center, Oregon State University.

07/91‑06/95 Associate Professor, Dept. Food Sci. & Tech., and Toxicology Prog., Oregon State University.

02/87‑06/91 Assistant Professor, Dept. Food Sci. & Tech., and Toxicology Prog., Oregon State University.

06/86‑02/87 Assistant Professor (Sr. Res.), Department of Agricultural Chemistry, Oregon State University.

07/85‑06/86 Research Assistant Professor, Dept. Biochemistry, Medical College of Wisconsin, Milwaukee.

07/84‑06/85 Instructor, Dept. Biochemistry, Medical College of Wisconsin.

11/82‑06/84 Research Associate, Dept. Biochemistry, Medical College of Wisconsin; under the direction of Dr.

Bettie Sue Masters.

09/16- Helen P. Rumbel Professorship for Cancer Prevention, Linus Pauling Institute, Oregon State Univ.

06/16- Research Member, Knight Cancer Prevention & Control Research Program, OHSU.

Professional Accomplishments

Curriculum Vitae: 
Credentials: 
Good House Keeping Seal of Approval
Professional Affiliations: 

American Association for Cancer Research (1989-present).

  1. Oregon State Legislative Committee (1998-2000).

American Chemical Society (1996-2011).

American Society of Biochemistry and Molecular Biology (1989-1998).

American Society for Pharmacology and Experimental Therapeutics (2002-present)

Elected-Councilor, Drug Metabolism Division (2004-2007)

International Society for the Study of Xenobiotics (1984-present).

Institute of Food Technologists (1988-1997).

Pacific Northwest Association of Toxicologists (1986-present).

Elected‑‑Secretary/Treasurer (1990‑92).

Elected--Vice President Elect (1994-1995), President Elect (1995-1996),President (1996-1997).

Society of Toxicology (1986-present).

Appointed--Program Committee (1991‑1994).

Elected--Education Committee (1997-1999)

Appointed--Co-Chair K-12 Education Committee (1997-1998); Chair (1998-1999)

Appointed-- Toxicology Education Foundation (1998-1999)

Elected--Secretary/Treasurer, Food Safety Specialty Section (1998-2000).

  1. Vice President Elect, Carcinogenesis Specialty Section (2009-2010); Vice President (2010-2011); President (2011-2012)
Employment: 

04/09-12/14 Director, Superfund Research Center, Oregon State University

01/02-03/09 Director, Marine/Freshwater Biomedical Sciences Center, Oregon State University.

07/98-06/01 Chief, Cancer Chemoprevention Program, Linus Pauling Institute, Oregon State University.

07/97-present Professor, Dept. Environmental and Molecular Toxicology, Oregon State University.

03/07-09/07 Interim Dept. Head, Environmental and Molecular Toxicology, Oregon State University

07/95-06/97 Professor, Dept. Food Sci. & Tech. and Toxicology Prog., Oregon State University.

07/94-06/06 Director, NIEHS Toxicology Training Grant, Oregon State University.

07/91-12/01 Deputy Director, Marine/Freshwater Biomedical Sciences Center, Oregon State University.

07/91‑06/95 Associate Professor, Dept. Food Sci. & Tech., and Toxicology Prog., Oregon State University.

02/87‑06/91 Assistant Professor, Dept. Food Sci. & Tech., and Toxicology Prog., Oregon State University.

06/86‑02/87 Assistant Professor (Sr. Res.), Department of Agricultural Chemistry, Oregon State University.

07/85‑06/86 Research Assistant Professor, Dept. Biochemistry, Medical College of Wisconsin, Milwaukee.

07/84‑06/85 Instructor, Dept. Biochemistry, Medical College of Wisconsin.

11/82‑06/84 Research Associate, Dept. Biochemistry, Medical College of Wisconsin; under the direction of Dr.

Bettie Sue Masters.

09/16- Helen P. Rumbel Professorship for Cancer Prevention, Linus Pauling Institute, Oregon State Univ.

Education: 

B.A. 1975 Reed College

Ph.D. 1982 Oregon State University

Service: 

ADVISORY/PEER REVIEW GROUPS

External Review--US‑EPA Laboratory, Gulf Breeze, Florida (1987)

Review Panel- US-EPA Eco-Related Life Sciences (1997)

Review Panel- US-EPA Ecosystem Indicators (1997)

Review Panel- US-EPA Eco-Related Life Sciences (1998)

Review Panel- US-EPA STAR Application for Endocrine Disruptors (January, 1999)

Review Panel- US-EPA STAR Fellowships in Aquatic Ecology and Ecosystems (Feb., 1999)

Review Panel- US-EPA STAR Fellowships in Aquatic Ecology and Ecosystems (March, 2000)

NIH, Metabolic Pathology Study Section (1995)

NIH, Special Study Section- Site Visit for P41 application (April, 1998)

NIH, AL-TOX 1 Study Section (1998-2003)

Chair, 2001-2003

NIH, NIEHS Special Review Panel (July, 1998)

NIH, Special Study Section- Reverse Site Visit for P41 application (March, 1999)

NIH, Special Review Panel (April, 2000)

National Academy of Sciences- Review of Draft Report “A Risk Reduction Strategy for PCB-Contaminated Sediments” (November, 2000)

NIH, Special Review Panel (ZES 1 BKW-C RO R RFA TW 01-002, International Training), June 13-15, 2001

NIH Special Review Group (ZES1 JAB-D-CO, NIEHS P01 grant), Feb. 4-5, 2004

NIH Special Review Group (ZRG1 BPC-M 40 1, NCRR P41 grant), April 4-6, 2004

NIH Special Review Group (ZES1 JAB-A-K1, NIEHS TIP grants), November 5, 2004

Pacific Northwest National Laboratory, Environmental Biomarkers Initiative External Advisory Committee, Feb., 2005- 2009.

NIH Special Review Group (NCI P01 Cluster Review Group- Subcommittee C-Basic and Preclinical), June 6-8, 2005.

NIH Special Emphasis Panel- Predictive ADME-Tox, NIGMS-ZGM1-127827, June 30-July 1, 2005.

National Water Research Institute’s Santa Ana River Monitoring Review Panel, Orange County Water District, November 15, 2005-present.

NIH Special Emphasis Panel, NIEHS, Outstanding New Investigators in Environmental Health Sciences Grants, Research Triangle Park, March 14-15, 2006.

NIH Special Review Group (ZRG1 EMNR (03), March 20, 2006

NIH, XNDA Review Group (ad hoc), June 7-8, 2006

NIH, Special Review Group (ZRG1 MOSS-B, 02), November, 15, 2006.

NIH, Special Review Group (ZRG1 ONC-P (02) (M), February 16, 2007

NIH, Special Review Group for NCI, February 26, 2007

NIH, Special Review Group for NIEHS (ONES ZES1-JAB (C) (R1), March 13, Research Triangle Park, N.C.

NIH, Special Review Group for NCRR, Comparative Medicine Resources Special Emphasis Panel (ZRR1 CM-B (02): November 19, 2007

NIEHS Center for Children’s Environmental Health, Advisory Committee, Medical College of Wisconsin and University of Wisconsin, Madison, October 2007-2012.

NIH, NCRR Special Review Group for R24 grants, November 19, 2007.

NIH, NIEHS, Special Review Emphasis Panel for T32 Proposals1 LWJ-G (TG), November 27, 2007.

NIH, XNDA Review Panel, ad hoc, February 6, 2008, Washington, D.C.

NIH, SIEE Review Panel, ad hoc, October 16, 2008, Washington, D.C.

NIH, Special Review Group for NIEHS (ONES), February 10, Research Triangle Park, N.C.

NIH, Special Emphasis Panel, Systemic Injury by Environmental Exposure (SIEE), June 4,5, Washington D.C.

NIH, Xenobiotic and Nutrient Disposition and Action (XNDA) Study Section, Member, July 1,2009-June 30, 2013.

NIEHS, Superfund Basic Research Program Review Panel, Research Triangle Park, October 27-29, 2009.

NIH, NCRR Special Emphasis Panel, IDeA Networks of Biomedical Research Excellence (INBRE), November 12, 2009, Washington, D.C.

NIH, Native American Research Centers for Health (NARCHVI), Washington, D.C., December 7-8, 2009.

NIH, Chemo/Dietary Prevention Study Section, ad hoc, February 10-11, 2011, Washington, D.C.

External Advisory Committee, U19 Consortium, University of Texas at Galveston, November, 2010-present

External Advisory Committee, U19 Consortium, University of Florida, August 2011-present

NIH, NIEHS Review Panel, ZES1 JAB-D (V), Review of ViCTER Proposals, Research Triangle Park, N.C., June 12, 2012.

NIH, ZRG1 DKUS-D (55) Interventions for Health Promotion and Disease Prevention in Native American Populations, Washington, D.C., Nov. 7, 2012.

NIH, ZRG1 DKUS-A (50)R RFA: Native American Research Centers for Heath, Washington, D.C., Nov. 7-9, 2012.

NIH, NCI Special Emphasis Panel for the PREVENT Cancer Program, May 2, 2013.

NIH, NCI Special Emphasis Panel for the PREVENT Cancer Program, April 22, 2014.

NIH, NIH Special Emphasis Panel for R15 proposals (Co-Chair), ZRG DKUS-A, June 30, 2014.

NIH, NIEHS, ad hoc Systemic Injury by Environmental Exposure (SIEE), June 24,25, 2014, Durham, N.C.

NIH, NIEHS, ZES 1 JAB-D 1R, Outstanding New Environmental Scientist (ONES) Awards Review Committee, Research Triangle Park, N.C., July 22, 2014

Michigan State University, SRP External Advisory Committee, 2014-

Medical Research Council (UK) Special Reviewer, June, 2014

NIH, NIEHS, Systemic Injury by Environmental Exposure (SIEE) Study Section, Member, October, 2014- June, 2017.

BBSRC, UK, Special Grant Reviewer, March, 2015.

ZonMw and German Federal Ministry of Education and Research (BMBF), Review of Proposal for “Innovative Systems Toxicology for Alternatives to Animal Testing, March, 2015.

Invited Reviewer, Plan Cancer Environment-2015, INSERM, France, March, 2015.

Invited Reviewer, NCI PREVENT Cancer Program, 8th Meeting of the SRP, April 27, 2015.

Invited Reviewer, NIH, ZES1 JAB-J(KS) Special Emphasis Review Committee for Career (K) Awards, July 23, 2015.

Invited Reviewer, NCI PREVENT Cancer Program, 9th Meeting of the SRP, October 6, 2015.

Invited Reviewer, NIH Special Emphasis Panel ZRG1 DKUS-A 82, R15 grants, February 22, 2016.

Baylor University, SRP External Advisory Committee, 2015-

Invited Reviewer, NCI PREVENT Cancer Program, 10th Meeting of the SRP, April 13, 2016.

 

Invited Reviewer, Longer Life Foundation (single grant proposal), June, 2016

Invited Reviewer, R15 grant reviews, July 11, 2016

External Advisory Committee, Institute for Environmental Health, OHSU, November 14,15, 2016

Invited Reviewer and Chair, R15 grants (ZRG1 DKUS-J (82), March 28,29, 2017

Invited Reviewer, R15 grants (ZRG1 DKUS-J (82), July 26, 2017

Invited ad hoc reviewer, NIH Cancer and Disease Prevention (CDP), June 21-22, 2018, Washington, D.C.

Invited ad hoc reviewer, NIH Systemic Injury from Environmental Exposures (SIEE), June 28-29, Washington, D.C.

External Advisory Committee, NIEHS ONES Awardee Dr. Natalie Johnson, Texas A&M University, 2016-

Invited Reviewer, NIH NCI ZCA1 TCRB-J (C1) Contract Review Meeting, August 16, 2018

 

EDITORIAL BOARDS

Editorial Advisory Board, Toxicology and Applied Pharmacology (1998-2004)

Associate Editor, Toxicology and Applied Pharmacology (2004-present) AE for 279 manuscripts to date

Editorial Advisory Board, “An Evidence-based Approach to Dietary Phytochemicals”, 2006, Thieme Medical Publishers

Editorial Advisory Board, An-Evidence-Based Approach to Phytochemicals and Other Dietary Factors, (j. Higdon, ed.), 2nd Edition,

 

Faculty Mentor: Dr. Abiba Tidoue, visiting Fulbright Fellow from Côte d”Ivoire

Faculty Mentor for K01 award, “Characterization of Histone Dephosphorylation in Breast Cancer Cells, NIH CA122177 to Dr. Pedro Rodriguez-Collazo, Assistant Professor, College of Osteopathic Medicine of the Pacific Northwest, Western University of Health Sciences, Lebanon, OR.

Faculty Member for NIEHS K01 Award, Dr. Mousa Diawara, University of Colorado, Pueblo, hosted for summers of 1996, 1997.

Promotion and Tenure Dossier Review, Dr. Céline Godard-Codding, Texas Tech University, July, 2018

Promotion Review Dossier Review, Dr. Natalie Johnson, Texas A&M University, July, 2018

 

Team or Collaborative Efforts

 

Director, NIEHS Toxicology Training Grant, 1994-2006

Director, Marine and Freshwater Biomedical Sciences Center, 2002-2009

Director, Superfund Research Center, 2009-2014


 

My Awards

Honors and Awards: 

 

Recipient‑‑Parker B. Francis Postdoctoral Fellowship in Pulmonary Research from the Puritan‑Bennett Foundation (1984‑1986).

Recipient—Oregon State University Phi Kappa Phi Honor Society Emerging Scholar Faculty Award (1990)

Recipient--Gary E. Costley Award in Nutrition from Kellogs (1992)

Recipient--Institute of Food Technologists Certificate of Merit for Authorship of "Potential Mechanisms for Food-Related Carcinogens and Anticarcinogens", a Scientific Status Summary.

Recipient--Oregon State University College of Agricultural Sciences Earl Price Award for Excellence in Research (1996).

Recipient- Certification of Appreciation in recognition of outstanding service to persons with disabilities, University Advisory Committee for Persons with Disabilities, Oregon State University

Recipient—Oregon State University College of Agricultural Sciences Agricultural Research Foundation Distinguished Faculty Award (2008).

Recipient—Oregon State University Alumni Association Distinguished Professor Award (2009)

Recipient- U.S. Environmental Protection Agency, Scientific and Technological Achievement Award, Honorable Mention, Developing, Proteomic Methods to Screen Environmental Chemicals for Endocrine Activity (2012)

Recipient- Pacific Northwest Association of Toxicologists Achievement Award (2014)

Recipient—Oregon State University Roy G. Arnold/Agricultural Research Foundation Leadership Award (2015)

Recipient- Oregon State University College of Agricultural Sciences, James and Mildred Oldfield and E.R. Jackman Foundation Team Award (Superfund Research Program Team) (2015)

Recipient-Western Association of Agricultural Experiment Station Directors Award of Excellence for project “Beneficial and Adverse Effects of Natural Chemicals on Human Health and Safety” (2015)

Recipient-Western Association of Agricultural Experiment Station Directors Award of Excellence for project “Beneficial and Adverse Effects of Natural Chemicals on Human Health and Safety” (2016)

My Publications

Proceedings and Conference Presentations: 

"Characterization and Regulation of an Extrahepatic Form of Rabbit FAD‑Containing Monooxygenase", presented at the 1986 meeting of the American Society of Biological Chemistry.

Seminar: "Factors Regulating the Activity of the Flavin‑Containing Monooxygenase", Fourth International Symposium on the Biological Oxidation of Nitrogen in Organic Molecules (Session Co‑Chairman), September 1989, Munich, West Germany.

Invited Speaker: 1991 Gordon Research Conference on Drug Metabolism, July 1991, Hanover, NH.

Invited Speaker: 1992 Symposium "Molecular Biology and Enzymology of the Multisubstrate Flavin-Containing Monooxygenase Gene Family", April 1992, FASEB meeting, Anaheim, CA.

Symposium Co-Chair: "Molecular Biology of Flavin-Containing Monooxygenase", 1993, Society of Toxicology meeting, Dallas, TX.

Invited Speaker: 1995 Gordon Research Conference on Phycotoxins and Mycotoxins, June, 1995, Plymouth, NH.

Invited Plenary Lecture: "Dietary Modulation of Flavin-Containing Monooxygenase", October 1996, ISSX, San Diego.

Invited Speaker: "Dietary Regulation of Flavin-Containing Monooxygenase (FMO) in Animals", March, 1999, First International Workshop on Trimethylaminuria, NIH, Bethesda, MD.

Session Chair and Member of the International Scientific Program Advisory Committee: “Sixth International Symposium on Biological Reactive Intermediates”, July, 2000, Paris, France.

 

Invited Speaker: “The Risks and Benefits of Chemoprotection of Cancer with Phytochemicals and Supplements: Focus on Indole-3-Carbinol and Dehydroepiandrosterone (DHEA)”, May, 2001, 30th International Conference of Nutritional Medicine Today, Toronto.

Seminar: “Developmental Regulation of Flavin-Containing Monooxygenases (FMOs) and Genetic Polymorphisms”, University of Wisconsin Environmental Health Sciences Center Annual Symposium, “Oxidative Metabolism: Potential Roles in Physiological Signaling and Toxicity, June 7-8, 2001, Madison, WI.

Invited Speaker: “Genetic Polymorphisms of Flavin-Containing Monooxygenase (FMO)”, 5th International Symposium on the Biological Oxidation of Nitrogen in Organic Molecules, Munich, Germany, October 4-6, 2001.

Invited Speaker: “Genetic Polymorphism in Expression of Human Flavin-Containing Monooxygenase Isoform 2: Role in Drug Metabolism”, Second Trimethylaminuria Workshop, March 15-16, 2002, NIH, Bethesda.

Invited Speaker: “FMO2 Expression: Influence of Genetic Variation and Developmental Factors”, Symposium on the Flavin-Containing Monooxygenase, ASPET annual meeting, New Orleans, April, 2002.

Invited Speaker: “The Rainbow Trout Model”, Symposium on Issues related to the use of fish in Toxicologic Pathology, Society of Toxicologic Pathology annual meeting, Denver, CO, June 4, 2002.

Invited Speaker: “A Genetic Polymorphism in Expression of Flavin-Containing Monooxygenase 2 in the Lung: Implications for Drug Metabolism”, The 2003 Robert S. Rozman Memorial Symposium, The Delaware Valley Drug Metabolism Discussion Group, Langhorne, PA, May 21, 2003.

Invited Speaker and Session Chair: “Potential of the Rainbow Trout Tumor Model in Cancer Risk Assessment”, Aquatic Animal Models of Human Disease Conference, Manassas, VA, September 29-October 2, 2003.

Invited Session Chair, “Mechanisms of Toxicity Gordon Conference”, Colby College, Waterville, Maine, July 23-28, 2006.

Invited Speaker, “Pharmacogenetics of Pulmonary Flavin-Containing Monooxygenase 2 (FMO2) in Humans”, 16th International Symposium on Microsomes and Drug Oxidations, Budapest, Hungary, September 3-7, 2006.

Invited Speaker, “Carcinogenicity of Polycyclic Aromatic Hydrocarbons”, 14th North American ISSX (International Society for the Study of Xenobiotics), Rio Grande, Puerto Rico, October 22-26, 2006.

Invited Speaker and Co-Chair, Symposium entitled “Recent Advances in our Understanding of the Flavin-Containing Monooxygenases: Role in Disease and Adverse Drug Reactions”, 2007 Experimental Biology, Washington D.C., April, 2007.

Invited Speaker, “The Maternal Diet of Mice Acts a Transplacental Cancer Chemoprotection Agent”, Diet and Optimum Health Conference, Portland, OR, May, 2007.

Organizing Committee and Invited Speaker, “4th Aquatic Animal Models of Human Disease Conference”, Duke University, January 31-February 3, 2008.

Invited Speaker, ASPET Symposium, “Targeting Drug Metabolizing Enzymes for Effective Chemopreventive Approaches”, April, 2009, New Orleans. Title of talk: “Chemoprevention of PAH transplacental cancer in a mouse model: role of Cyp1b1”.

Invited Speaker, ACS Symposium, Nutrigenomics: Food Components and Gene Interactions”, March, 22, 2010, San Francisco.

Invited Speaker, American Diabetes Association, Symposium on Pregnancy, Diet and Supplements- Needs and Concerns, “Epigenetics of Nutritionally Regulated Genes-Effects on the Fetus”, June 27, 2010, Orlando, Florida.

Organizing and Program Committee, “7th Internal Symposium on Biological Reactive Intermediates”, Barcelona, Spain, July, 2010.

Chair, Organizing Committee, “5th Aquatic Animal Models of Human Disease Conference”, Oregon State University, September, 2010.

Invited Speaker, “Maternal Dietary Supplements in Mice Provide Protection of Offspring against Adult Cancers”, Gulf Coast Society of Toxicology Annual Meeting, October 15, 2010, Houston, TX.

Chair, Planning Committee, NIEHS Superfund Research Program Annual Meeting, Portland, Oregon, November 10-12, 2010.

Invited speaker, “Studies on Cancer Chemoprevention”, Workshop on the Applications of Accelerator Mass Spectrometry in Biomedical and Clinical Research, NIH, June 21-22, 2011.

Invited Speaker, “The Importance of In Utero Versus Lactational Exposure in Lymphoma and Lung Cancer”, Gordon Research Conference, “Cellular and Molecular Mechanisms of Toxicity, August 8, 2011.

Member, Scientific Advisory Board, 17th North American ISSX Meeting, Atlanta, October, 2011.

Invited Speaker, “Transplacental Carcinogenesis due to Maternal Exposure to Individual PAHs and Environmental Mixtures: Impact of Dose, Timing of Exposure and Composition”, Society of Toxicology Workshop entitled “Novel Topics in Environmental Polycyclic Aromatic Hydrocarbon Metabolism Leading to Carcinogenesis”, San Francisco, CA, March, 2012.

Invited Speaker, Pacific Northwest Association of Toxicologists, “Polycyclic Aromatic Hydrocarbons (PAHs) as Transplacental Carcinogens”, Bothell, WA, September 19

Invited Symposium Speaker, National American Chemistry Society meeting, “Accelerator Mass Spectrometry (AMS) to Study ADME of Carcinogenic Polycyclic Aromatic Hydrocarbons Following Micro-Dosing in Humans”, Boston, MA, August 19, 2015.

Presentation, “PK Studies of Benzo[a]pyrene and Metabolites in Humans Utilizing Accelerator Mass Spectrometry”, W-3122 annual meeting, Portland, OR, October 6, 2016.

Invited Speaker, Linus Pauling Institute, Diet and Optimal Health Meeting, “Cancer Chemoprevention by Dietary Indoles” September 14, 2017, Oregon State University.

Invited Speaker, NIFA, Western States, W-4122 annual meeting, “Indole-3-Carbinol from Cruciferous Vegetables and Chemoprevention of Cancer from Dietary Ingestion of Polycyclic Aromatic Hydrocarbons (PAHs)”, October 5, 2017, Calistoga, CA.