Read more about Dr. Tanguay and his lab at: http://tanguaylab.com
Sinnhuber Aquatic Research Laboratory
Our laboratory has diverse research interests. For most of our studies we exploit the advantages of the zebrafish (Danio rerio) model to improve human health. We evaluate environmental biological interactions using a broad definition of the term “environment.” The human environment is the air we breath, the water we drink, the food we eat, the pharmaceuticals we take, the chemicals we are exposed to, etc. We then consider that there are underlying individual susceptibilities to these environmental insults, so if we can understand the mechanisms by which environmental exposures produce biological responses, we will be in a much stronger position to develop strategies to protect both humans and the environment. We have a long interest in better understanding the mechanism(s) underlying developmental toxicity in response to chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), ethanol, nicotine, and pesticides. We also have a regenerative medicine group that is developing new methods and approaches to discover the molecular pathways that prevent or promote vertebrate tissue regeneration. Finally, the nanotechnology division of our group is focused on defining the nonmaterial characteristics that dictate biological responses; with the goal to safely advance the field of nanotechnology. Trainees in my laboratory utilize several molecular, genetic and transgenic approaches to test their specific hypotheses.