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Found 32 results
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Kerkvliet, Nancy I
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2000
R. A. Prell
,
Dearstyne, E.
,
Steppan, L. G.
,
Vella, A. T.
, and
Kerkvliet, N. I.
,
“
CTL Hyporesponsiveness Induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin: Role of Cytokines and Apoptosis
”
,
Toxicology and Applied Pharmacology
, vol. 166, no. 3, pp. 214 - 221, 2000.
2001
B. A. Vorderstrasse
and
Kerkvliet, N. I.
,
“
2,3,7,8-Tetrachlorodibenzo-p-dioxin Affects the Number and Function of Murine Splenic Dendritic Cells and Their Expression of Accessory Molecules
”
,
Toxicology and Applied Pharmacology
, vol. 171, no. 2, pp. 117 - 125, 2001.
D. M. Shepherd
,
Steppan, L. B.
,
Hedstrom, O. R.
, and
Kerkvliet, N. I.
,
“
Anti-CD40 Treatment of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-Exposed C57Bl/6 Mice Induces Activation of Antigen Presenting Cells Yet Fails to Overcome TCDD-Induced Suppression of Allograft Immunity
”
,
Toxicology and Applied Pharmacology
, vol. 170, no. 1, pp. 10 - 22, 2001.
B. A. Vorderstrasse
,
Steppan, L. B.
,
Silverstone, A. E.
, and
Kerkvliet, N. I.
,
“
Aryl Hydrocarbon Receptor-Deficient Mice Generate Normal Immune Responses to Model Antigens and Are Resistant to TCDD-Induced Immune Suppression
”
,
Toxicology and Applied Pharmacology
, vol. 171, no. 3, pp. 157 - 164, 2001.
2002
C. E. Ruby
,
Leid, M.
, and
Kerkvliet, N. I.
,
“
2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin suppresses tumor necrosis Factor-$\alpha$ and Anti-CD40–Induced Activation of NF-$ąppa$B/Rel in dendritic cells: p50 Homodimer Activation is not affected
”
,
Molecular pharmacology
, vol. 62, pp. 722–728, 2002.
J. R. Maxwell
,
Ruby, C.
,
Kerkvliet, N. I.
, and
Vella, A. T.
,
“
Contrasting the roles of costimulation and the natural adjuvant lipopolysaccharide during the induction of T cell immunity
”
,
The Journal of Immunology
, vol. 168, pp. 4372–4381, 2002.
E. A. Dearstyne
and
Kerkvliet, N. I.
,
“
Mechanism of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-induced decrease in anti-CD3-activated CD4+ T cells: the roles of apoptosis, Fas, and TNF
”
,
Toxicology
, vol. 170, pp. 139–151, 2002.
N. I. Kerkvliet
,
“
Recent advances in understanding the mechanisms of TCDD immunotoxicity.
”
,
Int Immunopharmacol
, vol. 2, no. 2-3, pp. 277-91, 2002.
N. I. Kerkvliet
,
“
T Lymphocytes Are Direct, Aryl Hydrocarbon Receptor (AhR)-Dependent Targets of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD): AhR Expression in Both CD4+ and CD8+ T Cells Is Necessary for Full Suppression of a Cytotoxic T Lymphocyte Response by TCDD
”
,
Toxicology and Applied Pharmacology
, vol. 185, no. 2, pp. 146 - 152, 2002.
2003
J. - Y. Choi
,
Oughton, J. A.
, and
Kerkvliet, N. I.
,
“
Functional alterations in CD11b(+)Gr-1(+) cells in mice injected with allogeneic tumor cells and treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
”
,
Int Immunopharmacol
, vol. 3, no. 4, pp. 553-70, 2003.
B. A. Vorderstrasse
and
Kerkvliet, N. I.
,
“
Influence of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on the Antigen-Presenting Activity of Dendritic Cells
”
,
Toxicological Sciences
, vol. 72, no. 1, pp. 103 - 112, 2003.
2004
C. J. Funatake
and
Kerkvliet, N. I.
,
“
Early Consequences of 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure on the Activation and Survival of Antigen-Specific T Cells
”
,
Toxicological Sciences
, vol. 82, no. 1, pp. 129 - 142, 2004.
2005
C. J. Funatake
,
Marshall, N. B.
,
Steppan, L. B.
,
Mourich, D. V.
, and
Kerkvliet, N. I.
,
“
Cutting edge: activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin generates a population of CD4+ CD25+ cells with characteristics of regulatory T cells.
”
,
J Immunol
, vol. 175, no. 7, pp. 4184-8, 2005.
B. Mahadevan
,
Luch, A.
,
Bravo, C. F.
,
Atkin, J.
,
Steppan, L. B.
,
Pereira, C. B.
,
Kerkvliet, N. I.
, and
Baird, W. M.
,
“
Dibenzo[a,l]pyrene induced DNA adduct formation in lung tissue in vivo.
”
,
Cancer Lett
, vol. 227, no. 1, pp. 25-32, 2005.
B. Mahadevan
,
Luch, A.
,
Bravo, C. F.
,
Atkin, J.
,
Steppan, L. B.
,
Pereira, C. B.
,
Kerkvliet, N. I.
, and
Baird, W. M.
,
“
Dibenzo[a,l]pyrene induced DNA adduct formation in lung tissue in vivo
”
,
Cancer Letters
, vol. 227, no. 1, pp. 25 - 32, 2005.
2008
C. J. Funatake
,
Marshall, N. B.
, and
Kerkvliet, N. I.
,
“
Advertisement In utero Exposure of Mice to Dibenzo[a,l]Pyrene Produces Lymphoma in the Offspring: Role of the Aryl Hydrocarbon Receptor
”
,
Journal of Immunotoxicology
, vol. 5, no. 1, pp. 81 - 91, 2008.
2009
W. H. Bisson
,
Koch, D. C.
,
O'Donnell, E. F.
,
Khalil, S. M.
,
Kerkvliet, N. I.
,
Tanguay, R. L.
,
Abagyan, R.
, and
Kolluri, S. Kumar
,
“
Modeling of the aryl hydrocarbon receptor (AhR) ligand binding domain and its utility in virtual ligand screening to predict new AhR ligands.
”
,
J Med Chem
, vol. 52, no. 18, pp. 5635-41, 2009.
W. H. Bisson
,
Koch, D. C.
,
O'Donnell, E. F.
,
Khalil, S. M.
,
Kerkvliet, N. I.
,
Tanguay, R. L.
,
Abagyan, R.
, and
Kolluri, S. Kumar
,
“
Modeling of the aryl hydrocarbon receptor (AhR) ligand binding domain and its utility in virtual ligand screening to predict new AhR ligands
”
,
Journal of medicinal chemistry
, vol. 52, pp. 5635–5641, 2009.
W. H. Bisson
,
Koch, D. C.
,
Donnell, E. F. ’
,
Khalil, S. M.
,
Kerkvliet, N. I.
,
Tanguay, R. L.
,
Abagyan, R.
, and
Kolluri, S.
,
“
Modeling of the Aryl Hydrocarbon Receptor (AhR) Ligand Binding Domain and Its Utility in Virtual Ligand Screening to Predict New AhR Ligands
”
,
Journal of Medicinal Chemistry
, vol. 52, no. 18, pp. 5635 - 5641, 2009.
2010
E. F. O'Donnell
,
Saili, K. S.
,
Koch, D. C.
,
Kopparapu, P. R.
,
Farrer, D.
,
Bisson, W. H.
,
Mathew, L. K.
,
Sengupta, S.
,
Kerkvliet, N. I.
,
Tanguay, R.
, and
,
“
The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor
”
,
PLoS One
, vol. 5, p. e13128, 2010.
E. F. O'Donnell
,
Saili, K. S.
,
Koch, D. C.
,
Kopparapu, P. R.
,
Farrer, D.
,
Bisson, W. H.
,
Mathew, L. K.
,
Sengupta, S.
,
Kerkvliet, N. I.
,
Tanguay, R. L.
, and
Kolluri, S. Kumar
,
“
The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor.
”
,
PLoS One
, vol. 5, no. 10, 2010.
2012
E. F. O'Donnell
,
Kopparapu, P. Rao
,
Koch, D. C.
,
Jang, H. Sang
,
Phillips, J. Lynne
,
Tanguay, R. L.
,
Kerkvliet, N. I.
, and
Kolluri, S. Kumar
,
“
The aryl hydrocarbon receptor mediates leflunomide-induced growth inhibition of melanoma cells.
”
,
PLoS One
, vol. 7, no. 7, p. e40926, 2012.
2014
S. Punj
,
Kopparapu, P.
,
Jang, H. Sang
,
Phillips, J. Lynne
,
Pennington, J. M.
,
Rohlman, D.
,
O'Donnell, E. F.
,
Iversen, P. L.
,
Kolluri, S.
, and
Kerkvliet, N. I.
,
“
Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease.
”
,
PLoS One
, vol. 9, no. 2, p. e88726, 2014.
A. Perkins
,
Phillips, J. Lynne
,
Kerkvliet, N. I.
,
Tanguay, R. L.
,
Perdew, G. H.
,
Kolluri, S. K.
, and
Bisson, W. H.
,
“
A Structural Switch between Agonist and Antagonist Bound Conformations for a Ligand-Optimized Model of the Human Aryl Hydrocarbon Receptor Ligand Binding Domain.
”
,
Biology (Basel)
, vol. 3, no. 4, pp. 645-69, 2014.
A. Perkins
,
Phillips, J. Lynne
,
Kerkvliet, N. I.
,
Tanguay, R.
,
Perdew, G. H.
,
Kolluri, S.
, and
Bisson, W. H.
,
“
A structural switch between agonist and antagonist bound conformations for a ligand-optimized model of the human aryl hydrocarbon receptor ligand binding domain
”
,
Biology
, vol. 3, pp. 645–669, 2014.
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