TitleMuscadine grape (Vitis rotundifolia) and wine phytochemicals prevented obesity-associated metabolic complications in C57BL/6J mice.
Publication TypeJournal Article
Year of Publication2012
AuthorsGourineni, V, Shay, NF, Chung, S, Sandhu, AK, Gu, L
JournalJ Agric Food Chem
Volume60
Issue31
Pagination7674-81
Date Published2012 Aug 08
ISSN1520-5118
KeywordsAnimals, Blood Glucose, Body Weight, Fatty Acids, Nonesterified, Humans, Male, Mice, Mice, Inbred C57BL, Obesity, Plant Extracts, Vitis, Wine
Abstract

The objective of this study was to determine the effects of muscadine grape or wine (cv. Noble) phytochemicals on obesity and associated metabolic complications. Muscadine grape or wine phytochemicals were extracted using Amberlite FPX66 resin. Male C57BL/6J mice were given a low-fat diet (LF, 10% kcal fat), high-fat diet (HF, 60% kcal fat), HF + 0.4% muscadine grape phytochemicals (HF+MGP), or HF + 0.4% muscadine wine phytochemicals (HF+MWP) for 15 weeks. At 7 weeks, mice fed HF+MGP had significantly decreased body weights by 12% compared to HF controls. Dietary MGP or MWP supplementation reduced plasma content of free fatty acids, triglycerides, and cholesterol in obese mice. Inflammation was alleviated, and activity of glutathione peroxidase was enhanced. Consumption of MGP or MWP improved insulin sensitivity and glucose control in mice. Thus, consumption of muscadine grape and wine phytochemicals in the diet may help to prevent obesity-related metabolic complications.

DOI10.1021/jf3013663
Alternate JournalJ. Agric. Food Chem.
PubMed ID22788667