TitleMolecular signaling networks that choreograph epimorphic fin regeneration in zebrafish - a mini-review.
Publication TypeJournal Article
Year of Publication2010
AuthorsTal, TL, Franzosa, JA, Tanguay, RL
JournalGerontology
Volume56
Issue2
Pagination231-40
Date Published2010
ISSN1423-0003
KeywordsAnimal Structures, Animals, beta Catenin, Fibroblast Growth Factors, Hedgehog Proteins, Mesenchymal Stem Cells, Models, Biological, Multipotent Stem Cells, Regeneration, RNA, Untranslated, Signal Transduction, Tretinoin, Wnt Proteins, Wound Healing, Zebrafish, Zebrafish Proteins
Abstract

This short review provides a current synopsis of caudal fin regeneration in zebrafish with an emphasis on the molecular signaling networks that dictate epimorphic regeneration. At the outset, the fundamentals of caudal fin architecture and the stages of epimorphic regeneration are described. This is followed by a detailed look at the main networks implicated in fin regeneration, namely the Wnt, fibroblast growth factor, activin-betaA, retinoic acid and hedgehog signaling pathways. Throughout this mini-review, these molecular networks are examined through the lens of wound healing, blastema formation or regenerative outgrowth, three of the main stages of epimorphic regeneration. Next, the emerging role of noncoding RNAs as regulators of regeneration and mechanisms of regenerative termination are discussed. Finally, the implications for future research and the broader field of regenerative medicine are examined.

DOI10.1159/000259327
Alternate JournalGerontology
PubMed ID19923791
PubMed Central IDPMC2969159
Grant ListP30 ES000210 / ES / NIEHS NIH HHS / United States
T32 ES007060 / ES / NIEHS NIH HHS / United States
ES00210 / ES / NIEHS NIH HHS / United States
T32 ES07060 / ES / NIEHS NIH HHS / United States