TitleIL-10 prevents aging-associated inflammation and insulin resistance in skeletal muscle.
Publication TypeJournal Article
Year of Publication2017
AuthorsDagdeviren, S, Jung, DYoung, Friedline, RH, Noh, HLim, Kim, JHun, Patel, PR, Tsitsilianos, N, Inashima, K, Tran, DA, Hu, X, Loubato, MM, Craige, SM, Kwon, JYeon, Lee, KWon, Kim, JK
JournalFASEB J
Volume31
Issue2
Pagination701-710
Date Published2017 02
ISSN1530-6860
KeywordsAging, Animals, Creatine Kinase, MM Form, Energy Metabolism, Inflammation, Insulin Resistance, Interleukin-10, Male, Mice, Mice, Transgenic, Muscle, Skeletal
Abstract

Altered energy balance and insulin resistance are important characteristics of aging. Skeletal muscle is a major site of glucose disposal, and the role of aging-associated inflammation in skeletal muscle insulin resistance remains unclear. To investigate, we examined glucose metabolism in 18-mo-old transgenic mice with muscle-specific overexpression of IL-10 (M) and in wild-type mice during hyperinsulinemic-euglycemic clamping. Despite similar fat mass and energy balance, M mice were protected from aging-associated insulin resistance with significant increases in glucose infusion rates, whole-body glucose turnover, and skeletal muscle glucose uptake (∼60%; P < 0.05), as compared to age-matched WT mice. This protective effect was associated with decreased muscle inflammation, but no changes in adipose tissue inflammation in aging M mice. These results demonstrate the importance of skeletal muscle inflammation in aging-mediated insulin resistance, and our findings further implicate a potential therapeutic role of anti-inflammatory cytokine in the treatment of aging-mediated insulin resistance.-Dagdeviren, S., Jung, D. Y., Friedline, R. H., Noh, H. L., Kim, J. H., Patel, P. R., Tsitsilianos, N., Inashima, K., Tran, D. A., Hu, X., Loubato, M. M., Craige, S. M., Kwon, J. Y., Lee, K. W., Kim, J. K. IL-10 prevents aging-associated inflammation and insulin resistance in skeletal muscle.

DOI10.1096/fj.201600832R
Alternate JournalFASEB J.
PubMed ID27811060
PubMed Central IDPMC5240661
Grant ListR24 DK090963 / DK / NIDDK NIH HHS / United States
U24 DK093000 / DK / NIDDK NIH HHS / United States
R01 DK079999 / DK / NIDDK NIH HHS / United States
U2C DK093000 / DK / NIDDK NIH HHS / United States
R01 DK080756 / DK / NIDDK NIH HHS / United States