TitleIdentification of gold nanoparticle-resistant mutants of Saccharomyces cerevisiae suggests a role for respiratory metabolism in mediating toxicity.
Publication TypeJournal Article
Year of Publication2013
AuthorsSmith, MR, Boenzli, MG, Hindagolla, V, Ding, J, Miller, JM, Hutchison, JE, Greenwood, JA, Abeliovich, H, Bakalinsky, AT
JournalAppl Environ Microbiol
Volume79
Issue2
Pagination728-33
Date Published2013 Jan
ISSN1098-5336
KeywordsDrug Resistance, Fungal, Gene Deletion, Gold, Metabolic Networks and Pathways, Microbial Viability, Nanoparticles, Saccharomyces cerevisiae
Abstract

Positively charged gold nanoparticles (0.8-nm core diameter) reduced yeast survival, but not growth, at a concentration of 10 to 100 μg/ml. Among 17 resistant deletion mutants isolated in a genome-wide screen, highly significant enrichment was observed for respiration-deficient mutants lacking genes encoding proteins associated with the mitochondrion.

DOI10.1128/AEM.01737-12
Alternate JournalAppl. Environ. Microbiol.
PubMed ID23144132
PubMed Central IDPMC3553748
Grant ListP30 ES000210 / ES / NIEHS NIH HHS / United States