TitleThe Gene Ontology in 2010: extensions and refinements.
Publication TypeJournal Article
Year of Publication2010
JournalNucleic acids research
Volume38
PaginationD331-5
Date Published2010 Jan
ISSN1362-4962
KeywordsAnimals, Computational Biology, Controlled, Databases, Genetic, Genomics, Humans, Information Storage and Retrieval, Internet, Nucleic Acid, protein, Software, User-Computer Interface, Vocabulary
Abstract

The Gene Ontology (GO) Consortium (http://www.geneontology.org) (GOC) continues to develop, maintain and use a set of structured, controlled vocabularies for the annotation of genes, gene products and sequences. The GO ontologies are expanding both in content and in structure. Several new relationship types have been introduced and used, along with existing relationships, to create links between and within the GO domains. These improve the representation of biology, facilitate querying, and allow GO developers to systematically check for and correct inconsistencies within the GO. Gene product annotation using GO continues to increase both in the number of total annotations and in species coverage. GO tools, such as OBO-Edit, an ontology-editing tool, and AmiGO, the GOC ontology browser, have seen major improvements in functionality, speed and ease of use.