TitleChlorella vulgaris Attenuates Dermatophagoides Farinae-Induced Atopic Dermatitis-Like Symptoms in NC/Nga Mice.
Publication TypeJournal Article
Year of Publication2015
AuthorsKang, H, Lee, CHyung, Kim, JRhan, Kwon, JYeon, Seo, SGwon, Han, JGab, Kim, BGon, Kim, J-E, Lee, KWon
JournalInt J Mol Sci
Volume16
Issue9
Pagination21021-34
Date Published2015 Sep 02
ISSN1422-0067
KeywordsAnimals, Chemokines, Chlorella vulgaris, Dermatitis, Atopic, Dermatophagoides farinae, Dietary Supplements, Disease Models, Animal, Drug Administration Schedule, Eosinophils, Gene Expression Regulation, Humans, Immunosuppressive Agents, Male, Mast Cells, Mice
Abstract

Atopic dermatitis (AD) is a chronic and inflammatory skin disease that can place a significant burden on quality of life for patients. AD most frequently appears under the age of six and although its prevalence is increasing worldwide, therapeutic treatment options are limited. Chlorella vulgaris (CV) is a species of the freshwater green algae genus chlorella, and has been reported to modulate allergy-inducible factors when ingested. Here, we examined the effect of CV supplementation on AD-like symptoms in NC/Nga mice. CV was orally administrated for six weeks while AD-like symptoms were induced via topical application of Dermatophagoides farinae extract (DFE). CV treatment reduced dermatitis scores, epidermal thickness, and skin hydration. Histological analysis also revealed that CV treatment reduced DFE-induced eosinophil and mast cell infiltration into the skin, while analysis of serum chemokine levels indicated that CV treatment downregulated thymus- and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) levels. In addition, CV treatment downregulated mRNA expression levels of IL-4 and IFN-γ. Taken together, these results suggest that CV extract may have potential as a nutraceutical ingredient for the prevention of AD.

DOI10.3390/ijms160921021
Alternate JournalInt J Mol Sci
PubMed ID26404252
PubMed Central IDPMC4613239