Robert Tanguay

 roberttanguay

 

Distinguished Professor
Director of the NIEHS Toxicology Training Grant

Sinnhuber Aquatic Research Laboratory
Oregon State University
28645 East HWY 34
Corvallis, OR 97333
Phone (541) 737-6514
Fax (541) 737-0497

Ph.D., 1995, University of California - Riverside

robert.tanguay@oregonstate.edu

 

Read more about Dr. Tanguay and his lab at:

http://tanguaylab.com

 
Sinnhuber Aquatic Research Laboratory

Our laboratory has diverse research interests. For most of our studies we exploit the advantages of the zebrafish (Danio rerio) model to improve human health. We evaluate environmental biological interactions using a broad definition of the term “environment.” The human environment is the air we breath, the water we drink, the food we eat, the pharmaceuticals we take, the chemicals we are exposed to, etc. We then consider that there are underlying individual susceptibilities to these environmental insults, so if we can understand the mechanisms by which environmental exposures produce biological responses, we will be in a much stronger position to develop strategies to protect both humans and the environment. We have a long interest in better understanding the mechanism(s) underlying developmental toxicity in response to chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), ethanol, nicotine, and pesticides. We also have a regenerative medicine group that is developing new methods and approaches to discover the molecular pathways that prevent or promote vertebrate tissue regeneration. Finally, the nanotechnology division of our group is focused on defining the nonmaterial characteristics that dictate biological responses; with the goal to safely advance the field of nanotechnology. Trainees in my laboratory utilize several molecular, genetic and transgenic approaches to test their specific hypotheses.

 

Projects:

superfund

Project Leader, for Project 3 - PAH-Induced Developmental Toxicity

Polycyclic aromatic hydrocarbons (PAHs), derived largely from combustion of fossil fuels are widespread environmental contaminants that cross the placenta. Consequently, there is real risk of developmental exposure to PAHs causing adverse health outcomes for developing organisms. Despite potential developmental risks posed from individual or mixtures of PAHs, there are substantial information gaps regarding structure-developmental toxicity relationships. The most important information gap is arguably mechanism(s) underlying PAH toxicity.

Co-Investigator for Project 4 - Biological Response Indicator Devices

Research Coordinator for Administration Core A

 


oregoninvests

 


Recent Publications

  • Mathew, L.K., Sengupta, S. Perry, J., La Du, J, Andreasen, E.A. and Tanguay, R.L. Comparative Expression Profiling Reveals an Essential Role for Raldh2 in Epimorphic Regeneration J Biol Chem 284: 33642-53.

  • J. Li, X. Shang, Z. Zhao, R.L. Tanguay, Q. Dong, and C. Huang, Polycyclic aromatic hydrocarbons in water, sediment, soil, and plants of the Aojiang River waterway in Wenzhou, China. J Hazard Mater 173 75-81.

  • Huaping Shen, Changjiang Huang, Fang Lu, Junhu Yang, Robert Tanguay, Lu-Zhe Sun and Qiaoxiang Dong.Comparative toxicity of PCBs and PBDEs using human cancer cell lines and zebrafish embryos.  In Press Asian Journal of Ecotoxicology.

  • Kerri A. Stanley, Lawrence R. Curtis, Staci L. Massey Simonich, Robert L. Tanguay (2009). Endosulfan I and endosulfan sulfate disrupts zebrafish embryonic development. Aquat Toxicol 9: 355-61.

  • Bisson, W., D. Koch, E. O'Donnell, N. Kerkvliet, R.L. Tanguay, R. Abagyan, and S.K. Kolluri (2009). Structural Determinants of the Aryl Hydrocarbon Receptor Ligand Binding Domain. Journal of Medicinal Chemistry Manuscript. J Med Chem 52:5635-41.

  • Mathew, L. K., Simonich, M. T., Tanguay, R. L. (2009) AHR-dependent misregulation of Wnt signaling disrupts tissue regeneration. Biochem Pharmacol. 77, 498-507.

  • Vercruysse, K.P., S.L. Harper, D.M. Ivory, M.M. Whalen, K.S. Saili and R.L. Tanguay.  2008.  Potential anti-inflammatory properties of biologically-synthesized nanoparticles of gold or silver.  Nanotech 2008 2: 501-504.

  • Jinga, R., Huanga, C., Baia, C., Tanguay, R.L. and Donga, Q. Optimization of pre-freezing conditions for zebrafish sperm. (In Press Aquaculture).

  • Welsh, L., Tanguay, R.L. and Svoboda, K.R. Uncoupling nicotine mediated motoneuron axonal pathfinding errors and muscle degeneration in zebrafish, Toxicol Appl Pharmacol 237:29-40.

  • Tilton, F., La Du, J.K. and Tanguay, R.L. (2008) Sulfhydryl systems are a critical factor in the zebrafish developmental toxicity of the dithiocarbamate sodium metam (NaM). Aquatic Toxicology, 90(2) 121-7.

  • Tilton, F. and Tanguay, R.L. (2008) Exposure to sodium metam during zebrafish somitogenes results in early transcriptional indicators of the ensuing neuronal and muscular dysfunction. Toxicol Sci., 106(1)103-12.

  • Mathew, L.K., S.S. Sengupta, J. La Du, E.A. Andreasen, and R.L. Tanguay (2008). Crosstalk between AHR and Wnt signaling through R-Spondin1 impairs tissue regeneration in zebrafish. FASEB J,22:(8)3087-96.

Book Chapters:
  • Tanguay, R.L., Andreasen, E.A., Walker, M.E. and Peterson, R.E. (2003): Dioxin Toxicity and Aryl Hydrocarbon Receptor Signaling in Fish" in Dioxins and Health. Editor Schecter, A. New York: Plenum Press pp. 603-628.