OSU Course Catalog

TOX 360 THE WORLD OF POISONS (3)

Provides a basic understanding of how we are exposed and respond to chemicals, examples of human diseases associated with toxic insult, the role of technology and the interface of society and toxicology in risk perception and legislation. (Bacc Core Course) PREREQS: One 3-credit course in chemistry or one 3-credit course in biology.

TOX 401 RESEARCH (1-16)

TOX 405 READING AND CONFERENCE (1-16)

TOX 411 FUNDAMENTALS OF TOXICOLOGY (3)

Introduction to the discipline of toxicology. Examination of the basic concepts that define how chemicals are absorbed, distributed, metabolized, and eliminated by the body. Overview of associated dose/response relations. PREREQS: BB 350* or BB 450* or BB 490*

TOX 413 ENVIRONMENTAL TOXICOLOGY AND RISK ASSESSMENT (3)

Procedures for defining exposure and the use of toxicological data in defining risk assessment. Recent application of mechanistic concepts are reviewed. PREREQS: TOX 411

TOX 429 TOXIC SUBSTANCES IN FOOD (3)

Toxicology and epidemiology of human exposures to pesticides and food toxicants. PREREQS: BB 350* or BB 450* or BB 490*

TOX 429H TOXIC SUBSTANCES IN FOOD (3)

Toxicology and epidemiology of human exposures to pesticides and food toxicants. PREREQS: BB 350* or BB 450* or BB 490* and Honors College approval required.

TOX 430 CHEMICAL BEHAVIOR IN THE ENVIRONMENT (3)

Applications of chemical concepts in the definition and solution of pollution problems; analytical considerations, thermodynamic factors influencing movement of chemicals, physical and metabolic transformations occurring in the environment. PREREQS: CH 331 or CH 123 and Senior standing.

TOX 455 EXOTOXICOLOGY: AQUATIC ECOSYSTEMS (3)

Focuses on transport, fate, and effects of toxic substances in freshwater ecosystems. There is special emphasis on impacts on fish. PREREQS: CH 331

TOX 490 ENVIRONMENTAL FORENSIC CHEMISTRY (3)

Principles of Good Laboratory Practice Standards, methodology, utility and limitations of chemical forensic methods as applied to real investigations. PREREQS: One year of college chemistry and one term of organic chemistry.

TOX 499 SPECIAL TOPICS (1-16)

TOX 501 RESEARCH (1-16)

TOX 503 THESIS (1-16)

TOX 505 READING AND CONFERENCE (1-16)

TOX 507 SEMINAR (1-16)

TOX 511 FUNDAMENTALS OF TOXICOLOGY (3)

Introduction to the discipline of toxicology. Examination of the basic concepts that define how chemicals are absorbed, distributed, metabolized, and eliminated by the body. Overview of associated dose/response relations. Must be taken in order. PREREQS: BB 550* or BB 590*

TOX 512 TARGET ORGAN TOXICOLOGY (3)

Examination of toxicological effects of chemicals at organ level. Normal physiology of the organ system is received. PREREQS: TOX 511

TOX 513 ENVIRONMENTAL TOXICOLOGY AND RISK ASSESSMENT (3)

Procedures for defining exposure and the use of toxicological data in defining risk assessment. Recent application of mechanistic concepts are reviewed. PREREQS: TOX 511

TOX 514 MOLECULAR AND CELLULAR TOXICOLOGY (3)

Mechanisms of toxicant-induced cell proliferation, differentiation, or death. Emphasis is on metabolism, cell cycle regulation, mutagenesis, and initiation of cancer. PREREQS: BB 590 and BB 591 and BB 592 and TOX 511

TOX 529 TOXIC SUBSTANCES IN FOOD (3)

Toxicology and epidemiology of human exposures to pesticides and food toxicants. PREREQS: BB 350 or BB 450 or BB 490.

TOX 530 CHEMICAL BEHAVIOR IN THE ENVIRONMENT (3)

Applications of chemical concepts in the definition and solution of pollution problems; analytical considerations, thermodynamic factors influencing movement of chemicals, physical and metabolic transformations occurring in the environment. PREREQS: CH 106, CH 331, graduate standing.

TOX 554 GENOME ORGANIZATION, STRUCTURE, AND MAINTENANCE (4)

How diverse organisms store their individual sets of genetic information (genomes). Evolution of genomes and gene families. Structures of DNA and chromosomes. Biochemical and regulatory pathways that protect cellular genomes against environmental and endogenous damage and ensure transmission of faithful copies to progeny. Remodeling of genomes by recombination and transposition. CROSSLISTED as GEN 554 and MCB 554. PREREQS: BI 311 (genetics or equivalent), BB 450, BB 451, BB 452 or BB 490, BB 491, BB 492 (biochemistry) or equivalent.

TOX 555 ECOTOXICOLOGY: AQUATIC ECOSYSTEMS (3)

Focuses on transport, fate, and effects of toxic substances in freshwater ecosystems. There is special emphasis on impacts on fish. PREREQS: CH 331.

TOX 575 ADVANCED XENOBIOTIC METABOLISM (3)

Familiarizes students with basic principles of drug/xenobiotic metabolism. Concepts addressed include: how foreign chemicals or xenobiotics are absorbed, distributed, and metabolized; induction and inhibition of metabolism; effect of age, species, hormones, and disease on metabolism; genetic polymorphisms; effect of diet and environment; experimental techniques in xenobiotic metabolism; and regulatory issues (FDA and EPA). PREREQS: Graduate or professional pharmacy student standing.

TOX 590 ENVIRONMENTAL FORENSIC CHEMISTRY (3)

Principles of Good Laboratory Practice Standards, methodology, utility and limitations of chemical forensic methods as applied to real investigations. PREREQS: One year of college chemistry and one term of organic chemistry.

TOX 599 SPECIAL TOPICS (1-16)

TOX 601 RESEARCH (1-16)

TOX 603 THESIS (1-16)

TOX 605 READING AND CONFERENCE (1-16)

TOX 607 SEMINAR (1-16)

TOX 611 TESTING FOR GENOTOXICITY (4)

A lab-based course geared toward toxicology, biochemistry, biology, food science, nutrition, and pharmacy students. Introduces principles and methods of several key assays used to screen for DNA damage and mutation. These tests will include the following: (i) Salmonella mutagenicity assay ('Ames test'), (ii) single cell gel electrophoresis ('comet') assay, (iii) micronucleus assay, and (iv) PCR-based single strand conformation polymorphism (SSCP) screening for oncogene/tumor suppressor gene mutation in cancers. This short-duration, intensive lab/lecture class runs Mon-Fri, two weeks prior to the start of fall term. Each day includes laboratory work starting at 8 a.m., and a 2-hour lecture covering basic principles of the assays, as well as technical details of the experiment for the day. PREREQS: TOX 514 and BB 400 series, prior course work on DNA repair and mutagenesis, and/or instructor approval.

TOX 656 DNA REPAIR AND MUTAGENESIS (3)

Biochemical pathways by which cells maintain genomic stability by avoiding DNA mutation and breakage, including repair of DNA damage, DNA replication fidelity and replication error-correction processes, and bypass replication of damaged DNA. CROSSLISTED as BB 656. PREREQS: MCB 554 and MCB 555 and BB 492 or equivalent.

TOX 675 HUMAN CARCINOGENESIS (3)

Familiarizes students with the basic principles of molecular carcinogenesis with an emphasis on the current molecular understanding of cancer development in humans, and how such understanding influences diagnosis, treatment, and prevention strategies. PREREQS: TOX 514 and (MCB 555 or GEN 555) or BB 592 and Graduate or professional pharmacy standing.

TOX 699 SPECIAL TOPICS (1-16)

TOX 808 WORKSHOP (1-16)