Toxicological Sciences

Dr. Tanguay and his co-authors Lisa Truong, David Reif, Lindsey St. Mary, Mitra  Geier, and Hao Truong have learned that  their recent paper in Toxicological Sciences/"Multidimensional In Vivo Hazard Assessment Using Zebrafish"/  ( Tox Sci 137(1), 212--233, 2014)  received an Editors Highlight: http://toxsci.oxfordjournals.org/content/current (Safety Evaluation).

*Editor's Highlight:*  The Tanguay group uses the embryonic zebrafish model to demonstrate the utility of high throughput screening for toxicology studies. Thegroup evaluated the 1060 US EPA ToxCast Phase 1 and 2 compounds on 18 distinct outcomes. With four doses for each compound the group generated a dizzyingnumber of data points highlighting the importance of bioinformatics analysis in these types of studies. The study shows how it is now possible to screen many ofthe tens of thousands of untested chemicals using a whole animal model in which one can literally see developmental malformations. ---Gary W. Miller, Editor

 *http://toxsci.oxfordjournals.org/content/137/1/212.full.pdf+html*

Tanguay group